Pituitary gland

The pituitary gland, or hypophysis, is an endocrine gland about the size of a pea that sits in the small, bony cavity (sella turcica) at the base of the brain. Its posterior lobe is connected to a part of the brain called the hypothalamus via the infundibulum (or stalk), giving rise to the tuberoinfundibular pathway. The posterior lobe is thus derived from neural ectoderm while the anterior lobe is derived from oral ectoderm. The anterior pituitary lobe receives releasing hormones from the hypothalamus via a portal vein system. The pituitary gland secretes hormones regulating a wide variety of bodily activities, including trophic hormones that stimulate other endocrine glands. For a while, this led scientists to call it the master gland, but now we know that it is in fact regulated by releasing hormones from the hypothalamus. It is physically attached to the brain by the pituitary, or hypophyseal stalk connected with the median eminence.

The pituitary gland is divided into two sections: the anterior lobe (adenohypophysis) and the posterior lobe (neurohypophysis). The posterior pituitary is, in effect, a projection of the hypothalamus. It does not produce its own hormones, but only stores and releases the hormones oxytocin and antidiuretic hormone (ADH).

The anterior pituitary secretes growth hormone, prolactin, follicle-stimulating hormone, luteinizing hormone, thyroid-stimulating hormone, adrenocorticotropic hormone, endorphins and other hormones. It does this in response to a variety of chemical signals from the hypothalamus, including TRH, CRH, DA, GnRH, and GHRH, which travel to the anterior lobe by way of a special capillary system from the hypothalamus, down the median eminence, to the anterior lobe.

There is also an intermediate lobe in many animals. In adult humans it is just a thin layer of cells between the anterior and posterior pituitary, nearly indistinguishable from the anterior lobe. The intermediate lobe produces melanocyte-stimulating hormone (MSH), although this function is often (imprecisely) attributed to the anterior pituitary.

Functions

The pituitary gland helps control the following body processes:

• Growth
• Blood pressure
• Some aspects of pregnancy and childbirth)
• Breast milk production
• Sex organ functions in both women and men
• Thyroid gland function
• The conversion of food into energy (metabolism)
• Water balance in the body

See also

• Acromegaly
• Pickardt syndrome
• Pituitary adenoma
• Sheehan syndrome

External link

• The Pituitary Gland, from the UMM Endocrinology Health Guide

See also: Pituitary gland, Acromegaly, Adenohypophysis, Adrenal gland, Adrenocorticotropic hormone, Anterior pituitary, Antidiuretic hormone